Listen, O house of David! Is it not enough for you to weary men, must you also weary my God? Therefore, the Lord himself will give you this sign: the virgin shall be with child, and bear a son, and shall name him Immanuel. (Isaiah 7:10-14). King Ahaz’s people were in doubt. They wanted God to manifest himself in a conspicuous way, but He manifested himself in a very humble way; in the womb of His mother. The mighty God, all powerful, humbles himself by taking the human form, enclosed in the fleshy cocoon of the Virgin’s womb. The first time we hear about this sign is in the book of Genesis: And God told to the serpent: 'I will put enmity between you and the woman; between your seed and Hers' (Genesis). The woman is that sign. But why is that woman, the enemy of the serpent? She is the opposite of what the serpent represents. The serpent is rebellion; the woman is submission to the will of God. That is the sign that John describes in chapter 12 of the book of Revelation. It is a great sign: a woman clothed with the sun; standing on the moon; pregnant with child - a virgin and she is with child. This is the sign of the Immanuel, the new ark of the covenant, the mystery of creation revealed on the day the seventh angel blew his trumpet. A great sign appeared in the sky, a woman clothed with the sun, with the moon under her feet, and on her head a crown of twelve stars. She was with child and wailed aloud in pain as she labored to give birth. (Rev 12:1 – 2) That same sign was manifested to the Aztecs. When God imprinted the image of our Lady of Guadalupe on Juan Diego's tilma, and it was not something He came up with on the spot. He had that particular image in mind from the beginning of time: it was the Virgin, and She was with child. She gave birth to a son, a male child, destined to rule all the nations with an iron rod. Her child was caught up to God and his throne. (Rev 12:5) And what are the consequences of this sign? First, it is that creation was given from the Father to the Son to rule in the form of a man. Creation revolves around the Man God and therefore among humanity. In the same way that “God humble himself, taking on the form of a slave,” we are to do so, angels and men, without complaint since serving with love increases our virtues. And finally, we are to be the children of the Woman by “obeying God’s commandments and bearing witness to Jesus.” We are the children of that Woman who will crush the serpent’s head. We are the children of that Immaculate Vessel which for nine months gave shelter to the Unborn Child Jesus, and She is to be for eternity the Great Sign of the Immanuel.